Syntenin
From Proteopedia
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| - | <StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains ( | + | <StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (deep sky blue and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene='91/916387/Cv/1'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains<ref>PMID:16533050</ref>. | + | The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. <scene name='91/916387/Cv/4'>Syntenin/Syndecan peptide inreactions</scene>. Water molecules are shown as red spheres. |
==Syntenin 3D structures== | ==Syntenin 3D structures== | ||
Current revision
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References
- ↑ Friand V, David G, Zimmermann P. Syntenin and syndecan in the biogenesis of exosomes. Biol Cell. 2015 Oct;107(10):331-41. doi: 10.1111/boc.201500010. Epub 2015 Jun 30. PMID:26032692 doi:http://dx.doi.org/10.1111/boc.201500010
- ↑ Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS. The binding of the PDZ tandem of syntenin to target proteins. Biochemistry. 2006 Mar 21;45(11):3674-83. PMID:16533050 doi:10.1021/bi052225y
