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7ts0

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'''Unreleased structure'''
 
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The entry 7ts0 is ON HOLD until Paper Publication
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==Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein==
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<StructureSection load='7ts0' size='340' side='right'caption='[[7ts0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Zhao, L.-H., Lin, J., Mao, C., Zhou, X.E., Ji, S., Shen, D., Xiao, P., Melcher, K., Zhang, Y., Yu, X., Xu, H.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ts0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TS0 FirstGlance]. <br>
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Description: Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ts0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ts0 OCA], [https://pdbe.org/7ts0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ts0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ts0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ts0 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Zhang, Y]]
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== Function ==
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[[Category: Zhou, X.E]]
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[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
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[[Category: Xu, H.E]]
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__TOC__
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[[Category: Yu, X]]
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</StructureSection>
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[[Category: Zhao, L.-H]]
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[[Category: Homo sapiens]]
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[[Category: Lin, J]]
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[[Category: Large Structures]]
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[[Category: Melcher, K]]
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[[Category: Rattus norvegicus]]
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[[Category: Xiao, P]]
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[[Category: Synthetic construct]]
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[[Category: Shen, D]]
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[[Category: Ji S]]
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[[Category: Ji, S]]
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[[Category: Lin J]]
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[[Category: Mao, C]]
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[[Category: Mao C]]
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[[Category: Melcher K]]
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[[Category: Shen D]]
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[[Category: Xiao P]]
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[[Category: Xu HE]]
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[[Category: Yu X]]
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[[Category: Zhang Y]]
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[[Category: Zhao L-H]]
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[[Category: Zhou XE]]

Current revision

Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein

PDB ID 7ts0

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OCA

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