7r4k
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human mitochondrial NAD kinase== | ==Crystal structure of human mitochondrial NAD kinase== | ||
| - | <StructureSection load='7r4k' size='340' side='right'caption='[[7r4k]]' scene=''> | + | <StructureSection load='7r4k' size='340' side='right'caption='[[7r4k]], [[Resolution|resolution]] 3.33Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4k OCA], [https://pdbe.org/7r4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4k RCSB], [https://www.ebi.ac.uk/pdbsum/7r4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4k ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.33Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4k OCA], [https://pdbe.org/7r4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4k RCSB], [https://www.ebi.ac.uk/pdbsum/7r4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Progressive encephalopathy with leukodystrophy due to DECR deficiency. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.<ref>PMID:23212377</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[NAD kinase|NAD kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gelin M]] | [[Category: Gelin M]] | ||
Current revision
Crystal structure of human mitochondrial NAD kinase
| |||||||||||
Categories: Homo sapiens | Large Structures | Gelin M | Labesse G | Lionne C | Mary C
