7r4m
From Proteopedia
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==Crystal structure of mitochondrial NAD kinase== | ==Crystal structure of mitochondrial NAD kinase== | ||
| - | <StructureSection load='7r4m' size='340' side='right'caption='[[7r4m]]' scene=''> | + | <StructureSection load='7r4m' size='340' side='right'caption='[[7r4m]], [[Resolution|resolution]] 2.29Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4M FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4M FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4m OCA], [https://pdbe.org/7r4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4m RCSB], [https://www.ebi.ac.uk/pdbsum/7r4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4m ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4m OCA], [https://pdbe.org/7r4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4m RCSB], [https://www.ebi.ac.uk/pdbsum/7r4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Progressive encephalopathy with leukodystrophy due to DECR deficiency. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.<ref>PMID:23212377</ref> | ||
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| + | ==See Also== | ||
| + | *[[NAD kinase|NAD kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gelin M]] | [[Category: Gelin M]] | ||
Current revision
Crystal structure of mitochondrial NAD kinase
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Categories: Homo sapiens | Large Structures | Gelin M | Labesse G | Lionne C | Mary C
