7t7i
From Proteopedia
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| - | ==== | + | ==EBV nuclear egress complex== |
| - | <StructureSection load='7t7i' size='340' side='right'caption='[[7t7i]]' scene=''> | + | <StructureSection load='7t7i' size='340' side='right'caption='[[7t7i]], [[Resolution|resolution]] 3.97Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t7i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7I FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7i OCA], [https://pdbe.org/7t7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7i RCSB], [https://www.ebi.ac.uk/pdbsum/7t7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7i ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.97Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7i OCA], [https://pdbe.org/7t7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7i RCSB], [https://www.ebi.ac.uk/pdbsum/7t7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NEC2_EBVB9 NEC2_EBVB9] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04024]<ref>PMID:15731264</ref> <ref>PMID:16406456</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human herpesvirus 4 strain B95-8]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Heldwein EE]] |
| + | [[Category: Thorsen MK]] | ||
Current revision
EBV nuclear egress complex
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