7u8r

==Structure of porcine kidney V-ATPase with SidK, Rotary State 3==

<StructureSection load='7u8r' size='340' side='right'caption='[[7u8r]], [[Resolution|resolution]] 3.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[7u8r]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U8R FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u8r OCA], [https://pdbe.org/7u8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u8r RCSB], [https://www.ebi.ac.uk/pdbsum/7u8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u8r ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/VATA_PIG VATA_PIG] Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity).[UniProtKB:P38606]

==See Also==

*[[ATPase 3D structures|ATPase 3D structures]]

[[Category: Legionella pneumophila]]

[[Category: Tan YZ]]