7fgw
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 3: | Line 3: | ||
<StructureSection load='7fgw' size='340' side='right'caption='[[7fgw]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='7fgw' size='340' side='right'caption='[[7fgw]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7fgw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FGW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7fgw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FGW FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fgw OCA], [https://pdbe.org/7fgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fgw RCSB], [https://www.ebi.ac.uk/pdbsum/7fgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fgw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fgw OCA], [https://pdbe.org/7fgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fgw RCSB], [https://www.ebi.ac.uk/pdbsum/7fgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fgw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kamchonwongpaisan, S]] | ||
| - | [[Category: Saeyang, T]] | ||
| - | [[Category: Tarnchompoo, B]] | ||
| - | [[Category: Taweechai, S]] | ||
| - | [[Category: Vanichtanankul, J]] | ||
| - | [[Category: Yoomuang, A]] | ||
| - | [[Category: Yuthavong, Y]] | ||
| - | [[Category: Yuvaniyama, Y]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: Oxidoreductase]] | ||
| - | [[Category: Pyrimethamine]] | ||
| - | [[Category: Thymidylate synthase]] | ||
[[Category: Toxoplasma gondii]] | [[Category: Toxoplasma gondii]] | ||
| + | [[Category: Kamchonwongpaisan S]] | ||
| + | [[Category: Saeyang T]] | ||
| + | [[Category: Tarnchompoo B]] | ||
| + | [[Category: Taweechai S]] | ||
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Yoomuang A]] | ||
| + | [[Category: Yuthavong Y]] | ||
| + | [[Category: Yuvaniyama Y]] | ||
Current revision
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP
| |||||||||||
