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7yds
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7yds is ON HOLD Authors: Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W. Description: The structure of the bispecific antibody targe...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the bispecific antibody targeted PD-L1 and 4-1BB== |
| - | + | <StructureSection load='7yds' size='340' side='right'caption='[[7yds]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yds]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YDS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yds OCA], [https://pdbe.org/7yds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yds RCSB], [https://www.ebi.ac.uk/pdbsum/7yds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yds ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> |
| - | [[Category: Niu | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cheng LS]] | ||
| + | [[Category: Gao Y]] | ||
| + | [[Category: Liu WT]] | ||
| + | [[Category: Niu LW]] | ||
| + | [[Category: Zhu M]] | ||
| + | [[Category: Zhu ZL]] | ||
Current revision
The structure of the bispecific antibody targeted PD-L1 and 4-1BB
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Categories: Homo sapiens | Large Structures | Cheng LS | Gao Y | Liu WT | Niu LW | Zhu M | Zhu ZL
