1fn7

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(New page: 200px<br /> <applet load="1fn7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fn7, resolution 2.60&Aring;" /> '''COUPLING OF DAMAGE ...)
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[[Image:1fn7.gif|left|200px]]<br />
 
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<applet load="1fn7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fn7, resolution 2.60&Aring;" />
 
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'''COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN'''<br />
 
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==Disease==
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==COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN==
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Known disease associated with this structure: Renal cell carcinoma, clear cell, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601982 601982]]
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<StructureSection load='1fn7' size='340' side='right'caption='[[1fn7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fn7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FN7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fn7 OCA], [https://pdbe.org/1fn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fn7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fn7 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
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== Function ==
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[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fn7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fn7 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1FN7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FN7 OCA].
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein., Norman DP, Bruner SD, Verdine GL, J Am Chem Soc. 2001 Jan 17;123(2):359-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11456534 11456534]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bruner, S.D.]]
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[[Category: Bruner SD]]
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[[Category: Norman, D.P.G.]]
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[[Category: Norman DPG]]
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[[Category: Verdine, G.L.]]
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[[Category: Verdine GL]]
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[[Category: CA]]
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[[Category: ap lyase]]
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[[Category: base flipping]]
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[[Category: base recognition]]
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[[Category: base-exicision repair]]
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[[Category: dna glycosidase]]
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[[Category: dna glycosylase]]
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[[Category: dna repair]]
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[[Category: extrahelical dna]]
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[[Category: flipped-out base]]
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[[Category: helix hairpin helix]]
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[[Category: hydroxyguanine]]
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[[Category: mechanism-based inhibitor]]
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[[Category: oxoguanine]]
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[[Category: protein/dna]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:55:19 2007''
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Current revision

COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN

PDB ID 1fn7

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