7zvd
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+== | |
| - | + | <StructureSection load='7zvd' size='340' side='right'caption='[[7zvd]], [[Resolution|resolution]] 2.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZVD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | [[Category: Arbely | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zvd OCA], [https://pdbe.org/7zvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zvd RCSB], [https://www.ebi.ac.uk/pdbsum/7zvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zvd ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Nudelman | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN] Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:[https://omim.org/entry/305900 305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.<ref>PMID:1611091</ref> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN] Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arbely E]] | ||
| + | [[Category: Muskat NH]] | ||
| + | [[Category: Nudelman H]] | ||
| + | [[Category: Shahar A]] | ||
| + | [[Category: Wu F]] | ||
Current revision
K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+
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