8acb

Structural highlights

Function

A0A0Y0I2B8_9POTV An RNA-dependent RNA polymerase that plays an essential role in the virus replication.[ARBA:ARBA00029404] Has RNA-binding and proteolytic activities.[ARBA:ARBA00029399] Has helicase activity. It may be involved in replication.[ARBA:ARBA00029422] Indispensable for virus replication.[ARBA:ARBA00034080] Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.[ARBA:ARBA00029405] Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs (By similarity). Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation (By similarity). VPg-RNA directly binds EIF4E and is a template for transcription (By similarity). Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation.[ARBA:ARBA00037225] Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.[ARBA:ARBA00029420]

References

1. ↑ Chase O, Javed A, Byrne MJ, Thuenemann EC, Lomonossoff GP, Ranson NA, López-Moya JJ. CryoEM and stability analysis of virus-like particles of potyvirus and ipomovirus infecting a common host. Commun Biol. 2023 Apr 19;6(1):433. PMID:37076658 doi:10.1038/s42003-023-04799-x