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1fnl

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(New page: 200px<br /> <applet load="1fnl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fnl, resolution 1.8&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1fnl.gif|left|200px]]<br />
 
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<applet load="1fnl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fnl, resolution 1.8&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==
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Fc receptors play a major role in immune defenses against pathogens and in, inflammatory processes. The crystal structure of a human immunoglobulin, receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The, overall fold consists of two immunoglobulin-like domains with an acute, interdomain hinge angle of approximately 50 degrees. Trp-113, wedged, between the N-terminal D1 and the C-terminal D2 domains, appears to, further restrict the hinge angle. The putative Fc binding region of the, receptor carries a net positive charge complementary to the, negative-charged receptor binding regions on Fc. A 1:1 binding, stoichiometry between the receptor and Fc was measured by both the, equilibrium and nonequilibrium size-exclusion chromatography. Two separate, parallel dimers are observed in the crystal lattice, offering intriguing, models for receptor aggregation.
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<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
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Known diseases associated with this structure: Lupus erythematosus, systemic, susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146740 146740]], Neutropenia, alloimmune neonatal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146740 146740]], Viral infections, recurrent OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146740 146740]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [https://pdbe.org/1fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [https://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>
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1FNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
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Crystal structure of the extracellular domain of a human Fc gamma RIII., Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD, Immunity. 2000 Sep;13(3):387-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11021536 11021536]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnl ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boesen, C.C.]]
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[[Category: Boesen CC]]
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[[Category: Brooks, A.G.]]
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[[Category: Brooks AG]]
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[[Category: Fridman, W.H.]]
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[[Category: Fridman WH]]
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[[Category: Radaev, S.]]
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[[Category: Radaev S]]
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[[Category: Sautes-Fridman, C.]]
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[[Category: Sautes-Fridman C]]
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[[Category: Sun, P.D.]]
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[[Category: Sun PD]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: HG]]
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[[Category: beta sandwich]]
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[[Category: immunoglobulin-like]]
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[[Category: receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:55:30 2007''
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Current revision

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

PDB ID 1fnl

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