7pll
From Proteopedia
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| - | ==== | + | ==Structure of the murine cortactin C-SH3 domain in complex with a Pyk2 proline-rich ligand== |
<StructureSection load='7pll' size='340' side='right'caption='[[7pll]]' scene=''> | <StructureSection load='7pll' size='340' side='right'caption='[[7pll]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7pll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PLL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pll OCA], [https://pdbe.org/7pll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pll RCSB], [https://www.ebi.ac.uk/pdbsum/7pll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pll ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pll OCA], [https://pdbe.org/7pll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pll RCSB], [https://www.ebi.ac.uk/pdbsum/7pll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pll ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| + | [[Category: Chill JH]] | ||
| + | [[Category: Gil-Henn H]] | ||
| + | [[Category: Samson AO]] | ||
| + | [[Category: Sokolik CG]] | ||
Current revision
Structure of the murine cortactin C-SH3 domain in complex with a Pyk2 proline-rich ligand
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