3u01

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<StructureSection load='3u01' size='340' side='right'caption='[[3u01]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
<StructureSection load='3u01' size='340' side='right'caption='[[3u01]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Litpi Litpi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U01 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U01 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.12&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3phn|3phn]], [[3hg6|3hg6]], [[1onc|1onc]], [[1u00|1u00]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u01 OCA], [https://pdbe.org/3u01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u01 RCSB], [https://www.ebi.ac.uk/pdbsum/3u01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u01 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u01 OCA], [https://pdbe.org/3u01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u01 RCSB], [https://www.ebi.ac.uk/pdbsum/3u01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u01 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RNP30_RANPI RNP30_RANPI]] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
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[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Litpi]]
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[[Category: Lithobates pipiens]]
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[[Category: Kurpiewska, K]]
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[[Category: Kurpiewska K]]
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[[Category: Lewinski, K]]
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[[Category: Lewinski K]]
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[[Category: Loch, J]]
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[[Category: Loch J]]
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[[Category: Ribo, M]]
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[[Category: Ribo M]]
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[[Category: Torrent, G]]
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[[Category: Torrent G]]
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[[Category: Vilanova, M]]
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[[Category: Vilanova M]]
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[[Category: Alpha/beta protein]]
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[[Category: Antitumor protein]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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[[Category: Ranpirnase]]
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Current revision

Crystal structure of onconase double mutant C30A/C75A at 1.12 A resolution

PDB ID 3u01

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