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3ug6

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Current revision (10:23, 1 March 2024) (edit) (undo)
 
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<StructureSection load='3ug6' size='340' side='right'caption='[[3ug6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='3ug6' size='340' side='right'caption='[[3ug6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ug6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UG6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ug6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UG6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ug7|3ug7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ1142 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arsenite-transporting_ATPase Arsenite-transporting ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.16 3.6.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ug6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ug6 OCA], [https://pdbe.org/3ug6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ug6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ug6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ug6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ug6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ug6 OCA], [https://pdbe.org/3ug6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ug6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ug6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ug6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ARSA_METJA ARSA_METJA]] Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
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[https://www.uniprot.org/uniprot/ARSA_METJA ARSA_METJA] Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Efficient delivery of membrane proteins is a critical cellular process. The recently elucidated GET (Guided Entry of TA proteins) pathway is responsible for the targeted delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. The central player is the ATPase Get3, which in its free form exists as a dimer. Biochemical evidence suggests a role for a tetramer of Get3. Here, we present the first crystal structure of an archaeal Get3 homologue that exists as a tetramer and is capable of TA protein binding. The tetramer generates a hydrophobic chamber that we propose binds the TA protein. We use small-angle X-ray scattering to provide the first structural information of a fungal Get3/TA protein complex showing that the overall molecular envelope is consistent with the archaeal tetramer structure. Moreover, we show that this fungal tetramer complex is capable of TA insertion. This allows us to suggest a model where a tetramer of Get3 sequesters a TA protein during targeting to the membrane.
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Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue.,Suloway CJ, Rome ME, Clemons WM Jr EMBO J. 2011 Nov 29. doi: 10.1038/emboj.2011.433. PMID:22124326<ref>PMID:22124326</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ug6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arsenite-transporting ATPase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Metja]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Clemons, W M]]
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[[Category: Clemons Jr WM]]
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[[Category: Rome, M E]]
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[[Category: Rome ME]]
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[[Category: Suloway, C J.M]]
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[[Category: Suloway CJM]]
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[[Category: Arsa]]
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[[Category: Atp-binding]]
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[[Category: Atpase]]
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[[Category: Get3]]
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[[Category: Hydrolase]]
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[[Category: Membrane protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein targeting]]
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[[Category: Protein transport]]
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[[Category: Tail-anchored]]
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[[Category: Targeting factor]]
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[[Category: Trc40]]
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Current revision

Crystal Structure of Get3 from Methanocaldococcus jannaschii

PDB ID 3ug6

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