7yhr
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7yhr is ON HOLD Authors: Description: Category: Unreleased Structures) |
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- | '''Unreleased structure''' | ||
- | + | ==Anti-CRISPR protein AcrIC5== | |
+ | <StructureSection load='7yhr' size='340' side='right'caption='[[7yhr]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[7yhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_delhiensis Pseudomonas delhiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YHR FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yhr OCA], [https://pdbe.org/7yhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yhr RCSB], [https://www.ebi.ac.uk/pdbsum/7yhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yhr ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/A0A239N0M2_9PSED A0A239N0M2_9PSED] | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | As a result of the long-term battle of bacteria and archaea against invaders such as viruses and genetic mobile elements, they have developed CRISPR-Cas systems for self-defense, which allows them to remove the viral genetic material introduced into host cells via infection. To fight against this bacterial immune system, however, viruses have also evolved to produce multiple anti-CRISPR proteins that can inhibit the bacterial CRISPR-Cas system. In this study, we introduced a tentative inhibitory activity against a type I-C CRISPR-Cas system by determining the crystal structure of AcrIC5 from Pseudomonas delhiensis. Structural analysis revealed that AcrIC5 was composed of noble folds comprising two antiparallel sheets and three helices. Although AcrIC5 did not directly interact with either the type I-C cascade from Neisseria lactamia or the type I-F cascade from Pseudomonas aeruginosa in our analysis, a highly acidic surface feature indicated that AcrIC5 may be DNA mimic Acrs that directly binds to the target DNA binding site in type I-C cascade and inhibits the recruitment of the target DNA to this cascade. | ||
- | + | High-resolution crystal structure of the anti-CRISPR protein AcrIC5.,Kang YJ, Park HH Biochem Biophys Res Commun. 2022 Oct 15;625:102-108. doi: , 10.1016/j.bbrc.2022.08.005. Epub 2022 Aug 5. PMID:35952606<ref>PMID:35952606</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | [[Category: | + | </div> |
+ | <div class="pdbe-citations 7yhr" style="background-color:#fffaf0;"></div> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Pseudomonas delhiensis]] | ||
+ | [[Category: Kang YJ]] | ||
+ | [[Category: Park HH]] |
Current revision
Anti-CRISPR protein AcrIC5
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