7r97

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====
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==Crystal structure of postcleavge complex of Escherichia coli RNase III==
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<StructureSection load='7r97' size='340' side='right'caption='[[7r97]]' scene=''>
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<StructureSection load='7r97' size='340' side='right'caption='[[7r97]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7r97]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R97 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r97 OCA], [https://pdbe.org/7r97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r97 RCSB], [https://www.ebi.ac.uk/pdbsum/7r97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r97 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.804&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r97 OCA], [https://pdbe.org/7r97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r97 RCSB], [https://www.ebi.ac.uk/pdbsum/7r97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r97 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNC_ECOLI RNC_ECOLI] Digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. Involved in the processing of rRNA precursors, viral transcripts, some mRNAs and at least 1 tRNA (metY, a minor form of tRNA-init-Met). Cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs; cleavage can occur in assembled 30S, 50S and even 70S subunits and is influenced by the presence of ribosomal proteins. The E.coli enzyme does not cleave R.capsulatus rRNA precursor, although R.capsulatus will complement an E.coli disruption, showing substrate recognition is different. Removes the intervening sequences from Salmonella typhimurium rRNA precursor. Complements the pre-crRNA processing defect in an rnc deletion in S.pyogenes strain 370, although this E.coli strain does not have the corresponding CRISPR locus (strain TOP10) (PubMed:23535272).<ref>PMID:2085545</ref> <ref>PMID:23535272</ref> <ref>PMID:2406020</ref> <ref>PMID:2481042</ref> <ref>PMID:3903434</ref> <ref>PMID:4587248</ref> <ref>PMID:4592261</ref> <ref>PMID:4610145</ref> <ref>PMID:4865702</ref> <ref>PMID:6159890</ref> <ref>PMID:932008</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Dharavath S]]
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[[Category: Ji X]]
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[[Category: Shaw GX]]

Current revision

Crystal structure of postcleavge complex of Escherichia coli RNase III

PDB ID 7r97

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