7rgw
From Proteopedia
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==Crystal structure of HERC2 DOC domain== | ==Crystal structure of HERC2 DOC domain== | ||
| - | <StructureSection load='7rgw' size='340' side='right'caption='[[7rgw]]' scene=''> | + | <StructureSection load='7rgw' size='340' side='right'caption='[[7rgw]], [[Resolution|resolution]] 1.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RGW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RGW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rgw OCA], [https://pdbe.org/7rgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rgw RCSB], [https://www.ebi.ac.uk/pdbsum/7rgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rgw ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rgw OCA], [https://pdbe.org/7rgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rgw RCSB], [https://www.ebi.ac.uk/pdbsum/7rgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rgw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kutateladze TG]] | [[Category: Kutateladze TG]] | ||
[[Category: Liu J]] | [[Category: Liu J]] | ||
[[Category: Tencer AH]] | [[Category: Tencer AH]] | ||
Current revision
Crystal structure of HERC2 DOC domain
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