3us4
From Proteopedia
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<StructureSection load='3us4' size='340' side='right'caption='[[3us4]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='3us4' size='340' side='right'caption='[[3us4]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3us4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3us4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3US4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3US4 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3us4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3us4 OCA], [https://pdbe.org/3us4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3us4 RCSB], [https://www.ebi.ac.uk/pdbsum/3us4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3us4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3us4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3us4 OCA], [https://pdbe.org/3us4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3us4 RCSB], [https://www.ebi.ac.uk/pdbsum/3us4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3us4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/MATK_HUMAN MATK_HUMAN] Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.<ref>PMID:9171348</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Non-specific protein-tyrosine kinase]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: TCELL, Partnership for T-Cell Biology]] | ||
| - | [[Category: Jcsg]] | ||
| - | [[Category: Partnership for t-cell biology]] | ||
| - | [[Category: PSI, Protein structure initiative]] | ||
| - | [[Category: Psi-biology]] | ||
| - | [[Category: Sh2 domain]] | ||
| - | [[Category: Signaling protein]] | ||
| - | [[Category: Tcell]] | ||
| - | [[Category: Transferase]] | ||
Current revision
Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution
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