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3ux1

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Current revision (14:10, 14 March 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ux1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_9 Adeno-associated virus 9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UX1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ux1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_9 Adeno-associated virus 9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UX1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cap ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235455 Adeno-associated virus 9])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ux1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux1 OCA], [https://pdbe.org/3ux1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ux1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ux1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ux1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux1 OCA], [https://pdbe.org/3ux1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ux1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ux1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux1 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6JC40_9VIRU Q6JC40_9VIRU]
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Adeno-associated virus 9 (AAV9) has enhanced capsid-associated tropism for cardiac muscle and the ability to cross the blood brain barrier compared to other AAV serotypes. To help identify the structural features facilitating these properties, we have used cryo-electron microscopy (cryo-EM) and three-dimensional image reconstruction (cryo-reconstruction) and X-ray crystallography to determine the structure of the AAV9 capsid at 9.7 and 2.8-A resolution, respectively. The AAV9 capsid exhibits the surface topology conserved in all AAVs: depressions at each icosahedral twofold symmetry axis and surrounding each fivefold axis, three separate protrusions surrounding each threefold axis, and a channel at each fivefold axis. The AAV9 viral protein (VP) has a conserved core structure, consisting of an eight-stranded, beta-barrel motif and the alphaA helix, which are present in all parvovirus structures. The AAV9 VP differs in nine variable surface regions (VRs I to IX) when compared to AAV4, but at only three (VR-I, VR-II, and VR-IV) compared to AAV2 and AAV8. VR-I differences modify the raised region of the capsid surface between the twofold and fivefold depressions. The VR-IV difference produces smaller threefold protrusions in AAV9 that are less "pointed" compared to AAV2 and AAV8. Significantly, residues in the AAV9 VRs have been identified as important determinants of cellular tropism and transduction and dictate its antigenic diversity from AAV2. Hence, the AAV9 VRs likely confer the unique infection phenotypes of this serotype.
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Structural insight into the unique properties of Adeno-Associated Virus Serotype 9.,Dimattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A, Gurda BL, McKenna R, Olson NH, Sinkovits RS, Potter M, Byrne BJ, Aslanidi G, Zolotukhin S, Muzyczka N, Baker TS, Agbandje-McKenna M J Virol. 2012 Apr 11. PMID:22496238<ref>PMID:22496238</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ux1" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adeno-associated virus 9]]
[[Category: Adeno-associated virus 9]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Agbandje-McKenna, M]]
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[[Category: Agbandje-McKenna M]]
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[[Category: Aslanidi, G]]
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[[Category: Aslanidi G]]
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[[Category: Baker, T S]]
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[[Category: Baker TS]]
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[[Category: Bennett, A]]
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[[Category: Bennett A]]
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[[Category: Byrne, B J]]
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[[Category: Byrne BJ]]
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[[Category: DiMattia, M A]]
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[[Category: DiMattia MA]]
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[[Category: Gurda, B]]
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[[Category: Gurda B]]
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[[Category: McCall, A]]
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[[Category: McCall A]]
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[[Category: McKenna, R]]
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[[Category: McKenna R]]
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[[Category: Mitchell, M]]
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[[Category: Mitchell M]]
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[[Category: Muzyczka, N]]
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[[Category: Muzyczka N]]
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[[Category: Nam, H J]]
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[[Category: Nam H-J]]
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[[Category: Olson, N]]
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[[Category: Olson N]]
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[[Category: Potter, M]]
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[[Category: Potter M]]
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[[Category: Sakai, Y]]
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[[Category: Sakai Y]]
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[[Category: Sinkovitis, R]]
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[[Category: Sinkovitis R]]
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[[Category: Vliet, K Van]]
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[[Category: Van Vliet K]]
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[[Category: Zolotukhin, S]]
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[[Category: Zolotukhin S]]
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[[Category: Aav9]]
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[[Category: Virus]]
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Current revision

Structural Characterization of Adeno-Associated Virus Serotype 9

PDB ID 3ux1

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