3v2p

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<StructureSection load='3v2p' size='340' side='right'caption='[[3v2p]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='3v2p' size='340' side='right'caption='[[3v2p]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v2p]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V2P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v2p]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V2P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.873&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mz9|1mz9]], [[3v2n|3v2n]], [[3v2q|3v2q]], [[3v2r|3v2r]], [[3v2s|3v2s]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2p OCA], [https://pdbe.org/3v2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v2p RCSB], [https://www.ebi.ac.uk/pdbsum/3v2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2p OCA], [https://pdbe.org/3v2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v2p RCSB], [https://www.ebi.ac.uk/pdbsum/3v2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2p ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COMP_MOUSE COMP_MOUSE] May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Stetefeld, J]]
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[[Category: Stetefeld J]]
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[[Category: Coiled coil stearic acid]]
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[[Category: Protein binding]]
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[[Category: Storage]]
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Current revision

COMPcc in complex with fatty acids

PDB ID 3v2p

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OCA

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