7yg1

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'''Unreleased structure'''
 
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The entry 7yg1 is ON HOLD until Paper Publication
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==Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter==
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<StructureSection load='7yg1' size='340' side='right'caption='[[7yg1]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7yg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YG1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.77&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yg1 OCA], [https://pdbe.org/7yg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yg1 RCSB], [https://www.ebi.ac.uk/pdbsum/7yg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yg1 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/S12A3_HUMAN S12A3_HUMAN] Gitelman syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/S12A3_HUMAN S12A3_HUMAN] Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).[UniProtKB:P59158]<ref>PMID:18270262</ref> <ref>PMID:21613606</ref> <ref>PMID:22009145</ref> <ref>PMID:36351028</ref> <ref>PMID:36792826</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sodium-chloride cotransporter NCC mediates the coupled import of sodium and chloride across the plasma membrane, playing vital roles in kidney extracellular fluid volume and blood pressure control. Here, we present the full-length structure of human NCC, with 2.9 A for the transmembrane domain and 3.8 A for the carboxyl-terminal domain. NCC adopts an inward-open conformation and a domain-swap dimeric assembly. Conserved ion binding sites among the cation-chloride cotransporters and the Na2 site are observed in our structure. A unique His residue in the substrate pocket in NCC potentially interacts with Na1 and Cl1 and might also mediate the coordination of Na2 through a Ser residue. Putative observed water molecules are indicated to participate in the coordination of ions and TM coupling. Together with transport activity assays, our structure provides the first glimpse of NCC and defines ion binding sites, promoting drug development for hypertension targeting on NCC.
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Authors:
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Cryo-EM structure of the human sodium-chloride cotransporter NCC.,Nan J, Yuan Y, Yang X, Shan Z, Liu H, Wei F, Zhang W, Zhang Y Sci Adv. 2022 Nov 11;8(45):eadd7176. doi: 10.1126/sciadv.add7176. Epub 2022 Nov , 9. PMID:36351028<ref>PMID:36351028</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7yg1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Solute carrier family 12 3D structures|Solute carrier family 12 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Nan J]]
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[[Category: Shan ZY]]
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[[Category: Yang XM]]
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[[Category: Yuan YF]]
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[[Category: Zhang YQ]]

Current revision

Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter

PDB ID 7yg1

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