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3vw9

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Current revision (12:40, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3vw9' size='340' side='right'caption='[[3vw9]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
<StructureSection load='3vw9' size='340' side='right'caption='[[3vw9]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VW9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VW9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HPJ:1-HYDROXY-6-[1-(3-METHOXYPROPYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-4-PHENYLPYRIDIN-2(1H)-ONE'>HPJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GLO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HPJ:1-HYDROXY-6-[1-(3-METHOXYPROPYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-4-PHENYLPYRIDIN-2(1H)-ONE'>HPJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vw9 OCA], [https://pdbe.org/3vw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3vw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vw9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vw9 OCA], [https://pdbe.org/3vw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3vw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vw9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
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[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lactoylglutathione lyase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fukami, T A]]
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[[Category: Fukami TA]]
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[[Category: Irie, M]]
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[[Category: Irie M]]
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[[Category: Matsuura, T]]
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[[Category: Matsuura T]]
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[[Category: Glyoxalase]]
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[[Category: Lyase-lyase inhibitor complex]]
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Current revision

Human Glyoxalase I with an N-hydroxypyridone inhibitor

PDB ID 3vw9

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OCA

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