7yl1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7yl1 is ON HOLD Authors: Ahn, H.-C., Duong, M.T.H. Description: Crystal structure of JNK3 in complex with a fragment moledule [[Category: Unrelease...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of JNK3 in complex with a fragment molecule== | |
| - | + | <StructureSection load='7yl1' size='340' side='right'caption='[[7yl1]], [[Resolution|resolution]] 2.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YL1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J6F:7-hexyl-3-methyl-8-sulfanylidene-9H-purine-2,6-dione'>J6F</scene></td></tr> |
| - | [[Category: Ahn | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yl1 OCA], [https://pdbe.org/7yl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yl1 RCSB], [https://www.ebi.ac.uk/pdbsum/7yl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yl1 ProSAT]</span></td></tr> |
| - | [[Category: Duong | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[https://omim.org/entry/606369 606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ahn H-C]] | ||
| + | [[Category: Duong MTH]] | ||
Current revision
Crystal structure of JNK3 in complex with a fragment molecule
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