8afz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Architecture of the ESCPE-1 membrane coat== | |
| + | <StructureSection load='8afz' size='340' side='right'caption='[[8afz]], [[Resolution|resolution]] 10.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8afz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AFZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8afz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8afz OCA], [https://pdbe.org/8afz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8afz RCSB], [https://www.ebi.ac.uk/pdbsum/8afz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8afz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Recycling of membrane proteins enables the reuse of receptors, ion channels and transporters. A key component of the recycling machinery is the endosomal sorting complex for promoting exit 1 (ESCPE-1), which rescues transmembrane proteins from the endolysosomal pathway for transport to the trans-Golgi network and the plasma membrane. This rescue entails the formation of recycling tubules through ESCPE-1 recruitment, cargo capture, coat assembly and membrane sculpting by mechanisms that remain largely unknown. Herein, we show that ESCPE-1 has a single-layer coat organization and suggest how synergistic interactions between ESCPE-1 protomers, phosphoinositides and cargo molecules result in a global arrangement of amphipathic helices to drive tubule formation. Our results thus define a key process of tubule-based endosomal sorting. | ||
| - | + | Architecture of the ESCPE-1 membrane coat.,Lopez-Robles C, Scaramuzza S, Astorga-Simon EN, Ishida M, Williamson CD, Banos-Mateos S, Gil-Carton D, Romero-Durana M, Vidaurrazaga A, Fernandez-Recio J, Rojas AL, Bonifacino JS, Castano-Diez D, Hierro A Nat Struct Mol Biol. 2023 Jul;30(7):958-969. doi: 10.1038/s41594-023-01014-7. , Epub 2023 Jun 15. PMID:37322239<ref>PMID:37322239</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8afz" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Ishida | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Astorga-Simon E]] |
| - | [[Category: | + | [[Category: Banos-Mateos S]] |
| - | [[Category: | + | [[Category: Bonifacino JS]] |
| - | [[Category: | + | [[Category: Castano-Diez D]] |
| + | [[Category: Fernandez-Recio J]] | ||
| + | [[Category: Gil-Carton D]] | ||
| + | [[Category: Hierro A]] | ||
| + | [[Category: Ishida M]] | ||
| + | [[Category: Lopez-Robles C]] | ||
| + | [[Category: Rojas AL]] | ||
| + | [[Category: Romero M]] | ||
| + | [[Category: Scaramuzza S]] | ||
| + | [[Category: Vidaurrazaga A]] | ||
| + | [[Category: Williamsom CD]] | ||
Current revision
Architecture of the ESCPE-1 membrane coat
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