8dvc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Receptor ShHTL5 from Striga hermonthica in complex with strigolactone agonist GR24== | |
| + | <StructureSection load='8dvc' size='340' side='right'caption='[[8dvc]], [[Resolution|resolution]] 2.64Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8dvc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Striga_hermonthica Striga hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DVC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.638Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TZU:(3R,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methyl)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one'>TZU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dvc OCA], [https://pdbe.org/8dvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dvc RCSB], [https://www.ebi.ac.uk/pdbsum/8dvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dvc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0M5I297_STRHE A0A0M5I297_STRHE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Strigolactones (SLs) regulate many aspects of plant development, but ambiguities remain about how this hormone is perceived because SL-complexed receptor structures do not exist. We find that when SL binds the Striga receptor, ShHTL5, a series of conformational changes relative to the unbound state occur, but these events are not sufficient for signalling. Ligand-complexed receptors, however, form internal tunnels that posit an explanation for how SL exits its receptor after hydrolysis. | ||
| - | + | Structural analysis of a hormone-bound Striga strigolactone receptor.,Arellano-Saab A, Skarina T, Xu Z, McErlean CSP, Savchenko A, Lumba S, Stogios PJ, McCourt P Nat Plants. 2023 Jun 1. doi: 10.1038/s41477-023-01423-y. PMID:37264151<ref>PMID:37264151</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8dvc" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Striga hermonthica]] | ||
| + | [[Category: Arellano-Saab A]] | ||
| + | [[Category: McCourt P]] | ||
| + | [[Category: Savchenko A]] | ||
| + | [[Category: Skarina T]] | ||
| + | [[Category: Stogios PJ]] | ||
| + | [[Category: Yim V]] | ||
Current revision
Receptor ShHTL5 from Striga hermonthica in complex with strigolactone agonist GR24
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