7fh2
From Proteopedia
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==Crystal structure of the first bromodomain of BRD4 in complex with 16D10== | ==Crystal structure of the first bromodomain of BRD4 in complex with 16D10== | ||
| - | <StructureSection load='7fh2' size='340' side='right'caption='[[7fh2]]' scene=''> | + | <StructureSection load='7fh2' size='340' side='right'caption='[[7fh2]], [[Resolution|resolution]] 2.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FH2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7fh2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FH2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fh2 OCA], [https://pdbe.org/7fh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fh2 RCSB], [https://www.ebi.ac.uk/pdbsum/7fh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fh2 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.492Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JI:N-[2-[2-[(E)-3-(2,5-dimethoxyphenyl)prop-2-enoyl]-4,5-dimethoxy-phenyl]ethyl]ethanamide'>4JI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fh2 OCA], [https://pdbe.org/7fh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fh2 RCSB], [https://www.ebi.ac.uk/pdbsum/7fh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fh2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hirasawa N]] | [[Category: Hirasawa N]] | ||
[[Category: Yokoyama T]] | [[Category: Yokoyama T]] | ||
Current revision
Crystal structure of the first bromodomain of BRD4 in complex with 16D10
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