7s95
From Proteopedia
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==Room-temperature Human Hsp90a-NTD bound to adenine== | ==Room-temperature Human Hsp90a-NTD bound to adenine== | ||
| - | <StructureSection load='7s95' size='340' side='right'caption='[[7s95]]' scene=''> | + | <StructureSection load='7s95' size='340' side='right'caption='[[7s95]], [[Resolution|resolution]] 1.71Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S95 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7s95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S95 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s95 OCA], [https://pdbe.org/7s95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s95 RCSB], [https://www.ebi.ac.uk/pdbsum/7s95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s95 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s95 OCA], [https://pdbe.org/7s95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s95 RCSB], [https://www.ebi.ac.uk/pdbsum/7s95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s95 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fischer M]] | [[Category: Fischer M]] | ||
Current revision
Room-temperature Human Hsp90a-NTD bound to adenine
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