3w67

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Current revision (12:51, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3w67' size='340' side='right'caption='[[3w67]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
<StructureSection load='3w67' size='340' side='right'caption='[[3w67]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w67]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W67 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w67]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W67 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PT:(2R)-3-{[(S)-HYDROXY{[(1S,2R,3R,4S,5S,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>3PT</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ttpa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PT:(2R)-3-{[(S)-HYDROXY{[(1S,2R,3R,4S,5S,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>3PT</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w67 OCA], [https://pdbe.org/3w67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w67 RCSB], [https://www.ebi.ac.uk/pdbsum/3w67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w67 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w67 OCA], [https://pdbe.org/3w67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w67 RCSB], [https://www.ebi.ac.uk/pdbsum/3w67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w67 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TTPA_MOUSE TTPA_MOUSE]] Binds alpha-tocopherol and enhances its transfer between separate membranes (By similarity).
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[https://www.uniprot.org/uniprot/TTPA_MOUSE TTPA_MOUSE] Binds alpha-tocopherol and enhances its transfer between separate membranes (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Ohto, U]]
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[[Category: Ohto U]]
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[[Category: Satow, Y]]
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[[Category: Satow Y]]
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[[Category: Alpha-tocopherol]]
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[[Category: Alpha-tocopherol transfer]]
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[[Category: Ataxia]]
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[[Category: Aved]]
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[[Category: Disease mutation]]
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[[Category: Phosphatidyl inositol phosphate]]
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[[Category: Tocopherol]]
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[[Category: Transfer protein]]
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[[Category: Transport protein]]
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[[Category: Vitamin e]]
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[[Category: Vitamin e deficiency]]
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Current revision

Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate

PDB ID 3w67

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