3w9f

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Current revision (12:59, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3w9f' size='340' side='right'caption='[[3w9f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3w9f' size='340' side='right'caption='[[3w9f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w9f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W9F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w9f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W9F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w9g|3w9g]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPV4, VR-OAC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9f OCA], [https://pdbe.org/3w9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w9f RCSB], [https://www.ebi.ac.uk/pdbsum/3w9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w9f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9f OCA], [https://pdbe.org/3w9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w9f RCSB], [https://www.ebi.ac.uk/pdbsum/3w9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w9f ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV4_CHICK TRPV4_CHICK] Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by phorbol esters (PubMed:19864432). Channel activity seems to be regulated by a calmodulin-dependent mechanism (By similarity).[UniProtKB:Q9HBA0]<ref>PMID:11081638</ref> <ref>PMID:19864432</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chick]]
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[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hamada-nakahara, S]]
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[[Category: Hamada-nakahara S]]
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[[Category: Itoh, Y]]
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[[Category: Itoh Y]]
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[[Category: Suetsugu, S]]
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[[Category: Suetsugu S]]
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[[Category: Ankyrin repeat domain]]
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[[Category: Ard]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the ankyrin repeat domain of chicken TRPV4 in complex with IP3

PDB ID 3w9f

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