3wqo

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Current revision (08:46, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3wqo' size='340' side='right'caption='[[3wqo]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
<StructureSection load='3wqo' size='340' side='right'caption='[[3wqo]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ1311 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wqo OCA], [https://pdbe.org/3wqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wqo RCSB], [https://www.ebi.ac.uk/pdbsum/3wqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wqo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wqo OCA], [https://pdbe.org/3wqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wqo RCSB], [https://www.ebi.ac.uk/pdbsum/3wqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wqo ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Y1311_METJA Y1311_METJA]
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The crystal structure of a D-tagatose 3-epimerase-like protein (MJ1311p) encoded by a hypothetical open reading frame, MJ1311, in the genome of the hyperthermophilic archaeon Methanocaldococcus jannaschii was determined at a resolution of 2.64 A. The asymmetric unit contained two homologous subunits, and the dimer was generated by twofold symmetry. The overall fold of the subunit proved to be similar to those of the D-tagatose 3-epimerase from Pseudomonas cichorii and the D-psicose 3-epimerases from Agrobacterium tumefaciens and Clostridium cellulolyticum. However, the situation at the subunit-subunit interface differed substantially from that in D-tagatose 3-epimerase family enzymes. In MJ1311p, Glu125, Leu126 and Trp127 from one subunit were found to be located over the metal-ion-binding site of the other subunit and appeared to contribute to the active site, narrowing the substrate-binding cleft. Moreover, the nine residues comprising a trinuclear zinc centre in endonuclease IV were found to be strictly conserved in MJ1311p, although a distinct groove involved in DNA binding was not present. These findings indicate that the active-site architecture of MJ1311p is quite unique and is substantially different from those of D-tagatose 3-epimerase family enzymes and endonuclease IV.
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Structure of D-tagatose 3-epimerase-like protein from Methanocaldococcus jannaschii.,Uechi K, Takata G, Yoneda K, Ohshima T, Sakuraba H Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):890-5. doi:, 10.1107/S2053230X14011005. Epub 2014 Jun 18. PMID:25005083<ref>PMID:25005083</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3wqo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Metja]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Ohshima, T]]
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[[Category: Ohshima T]]
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[[Category: Sakuraba, H]]
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[[Category: Sakuraba H]]
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[[Category: Takata, G]]
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[[Category: Takata G]]
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[[Category: Uechi, K]]
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[[Category: Uechi K]]
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[[Category: Yoneda, K]]
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[[Category: Yoneda K]]
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[[Category: Tim barrel]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of D-tagatose 3-epimerase-like protein

PDB ID 3wqo

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