7yox
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7yox is ON HOLD Authors: Zheng, J.F., Weng, Z.F., Liu, Y.F. Description: Cryo-EM structure of the N-terminal domain of hMCM8/9 and HROB [[Category:...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the N-terminal domain of hMCM8/9 and HROB== | |
| - | + | <StructureSection load='7yox' size='340' side='right'caption='[[7yox]], [[Resolution|resolution]] 3.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yox]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YOX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.95Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yox OCA], [https://pdbe.org/7yox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yox RCSB], [https://www.ebi.ac.uk/pdbsum/7yox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yox ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Weng | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MCM8_HUMAN MCM8_HUMAN] NON RARE IN EUROPE: Primary ovarian failure. The disease is caused by mutations affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCM8_HUMAN MCM8_HUMAN] Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093).[UniProtKB:Q9CWV1]<ref>PMID:15684404</ref> <ref>PMID:23401855</ref> <ref>PMID:26215093</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liu YF]] | ||
| + | [[Category: Weng ZF]] | ||
| + | [[Category: Zheng JF]] | ||
Current revision
Cryo-EM structure of the N-terminal domain of hMCM8/9 and HROB
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