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7s24
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==Crystal structure of the Na+/H+ antiporter NhaA at pH 6.5== | ==Crystal structure of the Na+/H+ antiporter NhaA at pH 6.5== | ||
| - | <StructureSection load='7s24' size='340' side='right'caption='[[7s24]]' scene=''> | + | <StructureSection load='7s24' size='340' side='right'caption='[[7s24]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S24 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7s24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S24 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s24 OCA], [https://pdbe.org/7s24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s24 RCSB], [https://www.ebi.ac.uk/pdbsum/7s24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s24 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s24 OCA], [https://pdbe.org/7s24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s24 RCSB], [https://www.ebi.ac.uk/pdbsum/7s24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s24 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NHAA_ECOLI NHAA_ECOLI] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.<ref>PMID:1645730</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brock J]] | [[Category: Brock J]] | ||
Current revision
Crystal structure of the Na+/H+ antiporter NhaA at pH 6.5
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