1fzv

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(New page: 200px<br /> <applet load="1fzv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fzv, resolution 2.00&Aring;" /> '''THE CRYSTAL STRUCTU...)
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[[Image:1fzv.gif|left|200px]]<br />
 
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<applet load="1fzv" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fzv, resolution 2.00&Aring;" />
 
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'''THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION'''<br />
 
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==Overview==
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==THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION==
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The angiogenic molecule placenta growth factor (PlGF) is a member of the, cysteine-knot family of growth factors. In this study, a mature isoform of, the human PlGF protein, PlGF-1, was crystallized as a homodimer in the, crystallographic asymmetric unit, and its crystal structure was elucidated, at 2.0 A resolution. The overall structure of PlGF-1 is similar to that of, vascular endothelial growth factor (VEGF) with which it shares 42% amino, acid sequence identity. Based on structural and biochemical data, we have, mapped several important residues on the PlGF-1 molecule that are involved, in recognition of the fms-like tyrosine kinase receptor (Flt-1, also known, as VEGFR-1). We propose a model for the association of PlGF-1 and Flt-1, domain 2 with precise shape complementarity, consider the relevance of, this assembly for PlGF-1 signal transduction, and provide a structural, basis for altered specificity of this molecule.
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<StructureSection load='1fzv' size='340' side='right'caption='[[1fzv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzv OCA], [https://pdbe.org/1fzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzv RCSB], [https://www.ebi.ac.uk/pdbsum/1fzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLGF_HUMAN PLGF_HUMAN] Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.<ref>PMID:21215706</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fzv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The angiogenic molecule placenta growth factor (PlGF) is a member of the cysteine-knot family of growth factors. In this study, a mature isoform of the human PlGF protein, PlGF-1, was crystallized as a homodimer in the crystallographic asymmetric unit, and its crystal structure was elucidated at 2.0 A resolution. The overall structure of PlGF-1 is similar to that of vascular endothelial growth factor (VEGF) with which it shares 42% amino acid sequence identity. Based on structural and biochemical data, we have mapped several important residues on the PlGF-1 molecule that are involved in recognition of the fms-like tyrosine kinase receptor (Flt-1, also known as VEGFR-1). We propose a model for the association of PlGF-1 and Flt-1 domain 2 with precise shape complementarity, consider the relevance of this assembly for PlGF-1 signal transduction, and provide a structural basis for altered specificity of this molecule.
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==About this Structure==
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The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.,Iyer S, Leonidas DD, Swaminathan GJ, Maglione D, Battisti M, Tucci M, Persico MG, Acharya KR J Biol Chem. 2001 Apr 13;276(15):12153-61. Epub 2000 Nov 7. PMID:11069911<ref>PMID:11069911</ref>
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1FZV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MPD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FZV OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution., Iyer S, Leonidas DD, Swaminathan GJ, Maglione D, Battisti M, Tucci M, Persico MG, Acharya KR, J Biol Chem. 2001 Apr 13;276(15):12153-61. Epub 2000 Nov 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11069911 11069911]
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</div>
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<div class="pdbe-citations 1fzv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Acharya, K.R.]]
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[[Category: Acharya KR]]
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[[Category: Battisti, M.]]
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[[Category: Battisti M]]
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[[Category: Iyer, S.]]
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[[Category: Iyer S]]
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[[Category: Leonidas, D.D.]]
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[[Category: Leonidas DD]]
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[[Category: Maglione, D.]]
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[[Category: Maglione D]]
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[[Category: Persico, M.G.]]
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[[Category: Persico MG]]
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[[Category: Swaminathan, G.J.]]
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[[Category: Swaminathan GJ]]
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[[Category: Tucci, M.]]
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[[Category: Tucci M]]
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[[Category: MPD]]
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[[Category: angiogenesis]]
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[[Category: cysteine-knot family]]
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[[Category: growth factor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:58:57 2007''
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Current revision

THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION

PDB ID 1fzv

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