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3wsx

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Current revision (13:26, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wsx' size='340' side='right'caption='[[3wsx]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3wsx' size='340' side='right'caption='[[3wsx]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wsx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wsx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wsy|3wsy]], [[3wsz|3wsz]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsx OCA], [https://pdbe.org/3wsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wsx RCSB], [https://www.ebi.ac.uk/pdbsum/3wsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsx OCA], [https://pdbe.org/3wsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wsx RCSB], [https://www.ebi.ac.uk/pdbsum/3wsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
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[https://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kitago, Y]]
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[[Category: Kitago Y]]
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[[Category: Nagae, M]]
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[[Category: Nagae M]]
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[[Category: Nakata, Z]]
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[[Category: Nakata Z]]
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[[Category: Nogi, T]]
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[[Category: Nogi T]]
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[[Category: Takagi, J]]
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[[Category: Takagi J]]
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[[Category: Beta-propeller]]
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[[Category: Protein binding]]
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[[Category: Receptor]]
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Current revision

SorLA Vps10p domain in ligand-free form

PDB ID 3wsx

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