3wyg

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Current revision (13:33, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wyg' size='340' side='right'caption='[[3wyg]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='3wyg' size='340' side='right'caption='[[3wyg]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wyg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_AWRI796 Saccharomyces cerevisiae AWRI796] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wyf|3wyf]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AWRI796_3356 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=764097 Baker's yeast]), CRM1, G8514, KAP124, XPO1, YGR218W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PKIA, PRKACN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [https://pdbe.org/3wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [https://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyg OCA], [https://pdbe.org/3wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyg RCSB], [https://www.ebi.ac.uk/pdbsum/3wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. [[https://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES).
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[https://www.uniprot.org/uniprot/GSP1_YEAST GSP1_YEAST] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Koyama, M]]
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[[Category: Saccharomyces cerevisiae AWRI796]]
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[[Category: Matsuura, Y]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Shirai, N]]
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[[Category: Koyama M]]
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[[Category: Gtp-binding protein-gtp-binding protein inhibitor complex]]
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[[Category: Matsuura Y]]
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[[Category: Heat repeat]]
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[[Category: Shirai N]]
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[[Category: Nuclear export]]
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Current revision

Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex

PDB ID 3wyg

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