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8dzl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the K39Q mutant of rat somatic Cytochrome c at 1.36A== | |
| - | + | <StructureSection load='8dzl' size='340' side='right'caption='[[8dzl]], [[Resolution|resolution]] 1.36Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8dzl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DZL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dzl OCA], [https://pdbe.org/8dzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dzl RCSB], [https://www.ebi.ac.uk/pdbsum/8dzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dzl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CYC_RAT CYC_RAT] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Brunzelle J]] | ||
| + | [[Category: Edwards BFP]] | ||
| + | [[Category: Huettemann M]] | ||
| + | [[Category: Morse P]] | ||
| + | [[Category: Vaishnav A]] | ||
| + | [[Category: Wan J]] | ||
Current revision
Structure of the K39Q mutant of rat somatic Cytochrome c at 1.36A
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