6l6k

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Current revision (10:52, 22 November 2023) (edit) (undo)
 
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==Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1==
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<StructureSection load='6l6k' size='340' side='right'caption='[[6l6k]]' scene=''>
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<StructureSection load='6l6k' size='340' side='right'caption='[[6l6k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6l6k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L6K FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6k OCA], [https://pdbe.org/6l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l6k RCSB], [https://www.ebi.ac.uk/pdbsum/6l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6k ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9HF:1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic+acid'>9HF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6k OCA], [https://pdbe.org/6l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l6k RCSB], [https://www.ebi.ac.uk/pdbsum/6l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6k ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Ito N]]
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[[Category: Kakuta H]]
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[[Category: Makishima M]]
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[[Category: Nakano S]]
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[[Category: Numoto N]]
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[[Category: Shimizu K]]

Current revision

Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1

PDB ID 6l6k

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