3znr
From Proteopedia
(Difference between revisions)
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<StructureSection load='3znr' size='340' side='right'caption='[[3znr]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='3znr' size='340' side='right'caption='[[3znr]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3znr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3znr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNR FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NU9:N-{[4-(4-PHENYL-1,3-THIAZOL-2-YL)TETRAHYDRO-2H-PYRAN-4-YL]METHYL}-3-[5-(TRIFLUOROMETHYL)-1,2,4-OXADIAZOL-3-YL]BENZAMIDE'>NU9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NU9:N-{[4-(4-PHENYL-1,3-THIAZOL-2-YL)TETRAHYDRO-2H-PYRAN-4-YL]METHYL}-3-[5-(TRIFLUOROMETHYL)-1,2,4-OXADIAZOL-3-YL]BENZAMIDE'>NU9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
- | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znr OCA], [https://pdbe.org/3znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znr RCSB], [https://www.ebi.ac.uk/pdbsum/3znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znr OCA], [https://pdbe.org/3znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znr RCSB], [https://www.ebi.ac.uk/pdbsum/3znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/HDAC7_HUMAN HDAC7_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.<ref>PMID:12239305</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Lobera | + | [[Category: Lobera m]] |
- | [[Category: Madauss | + | [[Category: Madauss k]] |
- | [[Category: Nolan | + | [[Category: Nolan m]] |
- | [[Category: Pohlhaus | + | [[Category: Pohlhaus d]] |
- | [[Category: Trump | + | [[Category: Trump r]] |
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Current revision
HDAC7 bound with inhibitor TMP269
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Categories: Homo sapiens | Large Structures | Lobera m | Madauss k | Nolan m | Pohlhaus d | Trump r