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3zxn

From Proteopedia

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Moorella thermoacetica RsbS S58E

Structural highlights

3zxn is a 2 chain structure with sequence from Moorella thermoacetica ATCC 39073. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q2RIF5_MOOTA

Publication Abstract from PubMed

The stressosome complex regulates downstream effectors in response to environmental signals. In Bacillus subtilis, it activates the alternative sigma factor sigma(B), leading to the upregulation of the general stress regulon. Herein, we characterize a stressosome-regulated biochemical pathway in Moorella thermoacetica. We show that the presumed sensor, MtR, and the scaffold, MtS, form a pseudo-icosahedral structure like that observed in B. subtilis. The N-terminal domain of MtR is structurally homologous to B. subtilis RsbR, despite low sequence identity. The affinity of the switch kinase, MtT, for MtS decreases following MtS phosphorylation and not because of structural reorganization. Dephosphorylation of MtS by the PP2C type phosphatase MtX permits the switch kinase to rebind the stressosome to reset the response. We also show that MtT regulates cyclic di-GMP biosynthesis through inhibition of a GG(D/E)EF-type diguanylate cyclase, demonstrating that secondary messenger levels are regulated by the stressosome.

The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling.,Quin MB, Berrisford JM, Newman JA, Basle A, Lewis RJ, Marles-Wright J Structure. 2012 Feb 8;20(2):350-63. PMID:22325782^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Quin MB, Berrisford JM, Newman JA, Basle A, Lewis RJ, Marles-Wright J. The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling. Structure. 2012 Feb 8;20(2):350-63. PMID:22325782 doi:http://dx.doi.org/10.1016/j.str.2012.01.003

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zxn"

@@ Line 3: / Line 3: @@
 <StructureSection load='3zxn' size='340' side='right'caption='[[3zxn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3zxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moota Moota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3zxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ztb|3ztb]], [[2vy9|2vy9]], [[3zt9|3zt9]], [[3zta|3zta]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxn OCA], [https://pdbe.org/3zxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxn RCSB], [https://www.ebi.ac.uk/pdbsum/3zxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxn ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q2RIF5_MOOTA Q2RIF5_MOOTA]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 25: / Line 27: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Moota]]
+[[Category: Moorella thermoacetica ATCC 39073]]
-[[Category: Basle, A]]
+[[Category: Basle A]]
-[[Category: Berrisford, J M]]
+[[Category: Berrisford JM]]
-[[Category: Lewis, R J]]
+[[Category: Lewis RJ]]
-[[Category: Marles-Wright, J]]
+[[Category: Marles-Wright J]]
-[[Category: Newman, J A]]
+[[Category: Newman JA]]
-[[Category: Quin, M B]]
+[[Category: Quin MB]]
-[[Category: Gene regulation]]
-[[Category: Transcription]]

3zxn

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Current revision

Moorella thermoacetica RsbS S58E

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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