4a0h

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Current revision (11:17, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4a0h' size='340' side='right'caption='[[4a0h]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='4a0h' size='340' side='right'caption='[[4a0h]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KAP:7-KETO-8-AMINOPELARGONIC+ACID'>KAP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.808&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a0f|4a0f]], [[4a0g|4a0g]], [[4a0r|4a0r]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KAP:7-KETO-8-AMINOPELARGONIC+ACID'>KAP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0h OCA], [https://pdbe.org/4a0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0h RCSB], [https://www.ebi.ac.uk/pdbsum/4a0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0h OCA], [https://pdbe.org/4a0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0h RCSB], [https://www.ebi.ac.uk/pdbsum/4a0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BIODA_ARATH BIODA_ARATH]] Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.
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[https://www.uniprot.org/uniprot/BIODA_ARATH BIODA_ARATH] Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arath]]
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[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Alban, C]]
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[[Category: Alban C]]
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[[Category: Cobessi, D]]
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[[Category: Cobessi D]]
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[[Category: Dumas, R]]
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[[Category: Dumas R]]
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[[Category: Ferrer, J L]]
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[[Category: Ferrer JL]]
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[[Category: Meinguet, C]]
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[[Category: Meinguet C]]
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[[Category: Pautre, V]]
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[[Category: Pautre V]]
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[[Category: Bio3-bio1]]
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[[Category: Biotin synthesis]]
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[[Category: Transferase]]
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Current revision

Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana bound to 7-keto 8-amino pelargonic acid (KAPA)

PDB ID 4a0h

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