1hyw

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[[Image:1hyw.gif|left|200px]]
 
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==SOLUTION STRUCTURE OF BACTERIOPHAGE LAMBDA GPW==
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The line below this paragraph, containing "STRUCTURE_1hyw", creates the "Structure Box" on the page.
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<StructureSection load='1hyw' size='340' side='right'caption='[[1hyw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HYW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyw OCA], [https://pdbe.org/1hyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hyw RCSB], [https://www.ebi.ac.uk/pdbsum/1hyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hyw ProSAT]</span></td></tr>
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{{STRUCTURE_1hyw| PDB=1hyw | SCENE= }}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE OF BACTERIOPHAGE LAMBDA GPW'''
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[https://www.uniprot.org/uniprot/HCP_LAMBD HCP_LAMBD] Plays a role in morphogenesis of the virion head after genome packaging. Presumably interacts with the portal vertex to stabilize the packaged DNA within the head after packaging. Probably binds to the head-tail connector protein FII.<ref>PMID:14569303</ref> <ref>PMID:20660769</ref> <ref>PMID:5022189</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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Protein W (gpW) from bacteriophage lambda is required for the stabilization of DNA within the phage head and for attachment of tails onto the head during morphogenesis. Although comprised of only 68 residues, it likely interacts with at least two other proteins in the mature phage and with DNA. Thus, gpW is an intriguing subject for detailed structural studies. We have determined its solution structure using NMR spectroscopy and have found it to possesses a novel fold consisting of two alpha-helices and a single two-stranded beta-sheet arranged around a well-packed hydrophobic core. The 14 C-terminal residues of gpW, which are essential for function, are unstructured in solution.
Protein W (gpW) from bacteriophage lambda is required for the stabilization of DNA within the phage head and for attachment of tails onto the head during morphogenesis. Although comprised of only 68 residues, it likely interacts with at least two other proteins in the mature phage and with DNA. Thus, gpW is an intriguing subject for detailed structural studies. We have determined its solution structure using NMR spectroscopy and have found it to possesses a novel fold consisting of two alpha-helices and a single two-stranded beta-sheet arranged around a well-packed hydrophobic core. The 14 C-terminal residues of gpW, which are essential for function, are unstructured in solution.
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==About this Structure==
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The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold.,Maxwell KL, Yee AA, Booth V, Arrowsmith CH, Gold M, Davidson AR J Mol Biol. 2001 Apr 20;308(1):9-14. PMID:11302702<ref>PMID:11302702</ref>
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1HYW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYW OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold., Maxwell KL, Yee AA, Booth V, Arrowsmith CH, Gold M, Davidson AR, J Mol Biol. 2001 Apr 20;308(1):9-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11302702 11302702]
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</div>
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[[Category: Enterobacteria phage lambda]]
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<div class="pdbe-citations 1hyw" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Arrowsmith, C H.]]
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<references/>
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[[Category: Booth, V.]]
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__TOC__
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[[Category: Davidson, A R.]]
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</StructureSection>
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[[Category: Gold, M.]]
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[[Category: Escherichia virus Lambda]]
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[[Category: Maxwell, K L.]]
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[[Category: Large Structures]]
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[[Category: Yee, A A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Novel fold]]
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[[Category: Booth V]]
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[[Category: One two-stranded beta-sheet]]
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[[Category: Davidson AR]]
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[[Category: Two helice]]
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[[Category: Gold M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:22:36 2008''
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[[Category: Maxwell KL]]
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[[Category: Yee AA]]

Current revision

SOLUTION STRUCTURE OF BACTERIOPHAGE LAMBDA GPW

PDB ID 1hyw

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