14-3-3 protein 3D structures
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*14-3-3 protein σ complex with peptide | *14-3-3 protein σ complex with peptide | ||
| - | **[[1ywt]], [[3iqj]], [[3iqu]], [[3lw1]], [[3mhr]], [[3p1n]], [[4dat]], [[4dau]], [[4fl5]], [[4jc3]], [[4jdd]], [[4iea]], [[4qli]], [[4y5i]], [[4y32]], [[ | + | **[[1ywt]], [[3iqj]], [[3iqu]], [[3lw1]], [[3mhr]], [[3p1n]], [[4dat]], [[4dau]], [[4fl5]], [[4jc3]], [[4jdd]], [[4iea]], [[4qli]], [[4y5i]], [[4y32]], [[5hf3]], [[5btv]], [[5mhc]], [[5moc]], [[5mxo]], [[5my9]], [[5myc]], [[5n5r]], [[5n5t]], [[5n5w]], [[5n75]], [[5ok9]], [[5okf]], [[5om0]], [[5oma]], [[5xy9]], [[6fau]], [[6fav]], [[6faw]], [[6fbb]], [[6fcp]], [[6fbw]], [[6fby]], [[6fi4]], [[6fi5]], [[6g6x]], [[6g8i]], [[6g8j]], [[6g8k]], [[6g8l]], [[6g8p]], [[6g8q]], [[6hhp]], [[6hkb]], [[6hkf]], [[6hmt]], [[6hmu]], [[6hn2]], [[6nv2]], [[6qiu]], [[6qdr]], [[6qds]], [[6qdt]], [[6qhl]], [[6qhm]], [[6qzr]], [[6qzs]], [[6r5l]], [[6rhc]], [[6rjl]], [[6rjq]], [[6rjz]], [[6rk8]], [[6rki]], [[6rkk]], [[6rkm]], [[6rl3]], [[6rl4]], [[6rl6]], [[6rm5]], [[6rm7]], [[6rp6]], [[6rwh]], [[6rwi]], [[6rwu]], [[6rx2]], [[6s3c]], [[6s40]], [[6s9q]], [[6sin]], [[6sio]], [[6sip]], [[6siq]], [[6slv]], [[6slw]], [[6slx]], [[6t5f]], [[6t5h]], [[6t80]], [[6tch]], [[6tjm]], [[6tl3]], [[6twz]], [[6w0l]], [[6xwd]], [[6y1d]], [[6y1j]], [[6y3m]], [[6y3o]], [[6y3r]], [[6y3s]], [[6y3v]], [[6y40]], [[6y44]], [[6y58]], [[6y7t]], [[6y8a]], [[6y8b]], [[6y8d]], [[6y8e]], [[6yia]], [[6yib]], [[6yic]], [[6ylu]], [[6yow]], [[6yox]], [[6yoy]], [[6yp2]], [[6yp3]], [[6yp8]], [[6ypl]], [[6ypy]], [[6yq2]], [[6yr5]], [[6yr6]], [[6yr7]], [[6zbt]], [[6zcj]], [[6zvb]], [[6zvc]], [[6zvd]], [[6zve]], [[7aew]], [[7aog]], [[7b13]], [[7b15]], [[7bm9]], [[7nfw]], [[7nix]], [[7nma]], [[7nmw]], [[7nmx]], [[7nn2]], [[7nnd]], [[7nne]], [[7np2]], [[7npb]], [[7npg]], [[7o07]], [[7o6o]], [[7ob5]], [[7obc]], [[7obg]], [[7obk]], [[7obs]], [[7obx]], [[7qik]], [[7qip]], [[7zit]], [[7zmu]], [[7zmw]], [[8anb]], [[8bfc]], [[8bi7]], [[8bx0]], [[8bx3]], [[8bx4]], [[8by9]], [[8byf]], [[8c04]], [[8c0k]], [[8c28]], [[8c2d]], [[8c2e]], [[8c2y]], [[8c3z]], [[8c40]], [[8p0d]] – hPRS + peptide <br /> |
**[[3p1p]], [[3p1r]], [[5lu1]], [[5lu2]] – hPRS (mutant) + peptide <br /> | **[[3p1p]], [[3p1r]], [[5lu1]], [[5lu2]] – hPRS (mutant) + peptide <br /> | ||
**[[5ltw]] – hPRS (mutant) + HSPB6 <br /> | **[[5ltw]] – hPRS (mutant) + HSPB6 <br /> | ||
| - | **[[3iqv]], [[3o8i]], [[3p1o]], [[3ux0]], [[4fr3]], [[6ghp]], [[6xxc]], [[6xy5]], [[6y18]], [[6y3a]], [[7axn]], [[7ayf]], [[7az1]], [[7az2]], [[7b9m]], [[7b9r]], [[7b9t]], [[7ba3]], [[7ba5]], [[7ba6]], [[7ba7]], [[7ba8]], [[7ba9]], [[7baa]], [[7bab]], [[7bdp]], [[7bdt]], [[7bdy]], [[7bfw]], [[7bg3]], [[7bgq]], [[7bgr]], [[7bgv]], [[7bgw]], [[7bi3]], [[7biq]], [[7biw]], [[7biy]], ]]7bjb]], [[7bjf]], [[7bjl]], [[7bjw]], [[7bkh]], [[7bmc]], [[7nif]], [[7nig]], [[7niz]], [[7nj6]], [[7nj8]], [[7nj9]], [[7nja]], [[7njb]], [[7nk3]], [[7nk5]], [[7nle]], [[7nm3]], [[7nqp]], [[7nrk]], [[7nrl]], [[7nla]], [[7nm1]], [[7nm9]], [[7nmh]], [[7nr7]], [[7nsv]], [[7nv4]], [[7nvi]], [[7nws]], [[7nxs]], [[7nxt]], [[7nxw]], [[7nxy]], [[7ny4]], [[7nyf]], [[7nz6]], [[7nzg]], [[7nye]], [[7nyg]], [[7nzk]], [[7nzv]], [[7o34]], [[7o3a]], [[7o3f]], [[7o3p]], [[7o3q]], [[7o3r]], [[7o3s]], [[7o57]], [[7o59]], [[7o5a]], [[7o5c]], [[7o5d]], [[7o5f]], [[7o5g]], [[7o5o]], [[7o5p]], [[7o5s]], [[7o5u]], [[7o5x]], [[7o6f]], [[7o6g]], [[7o6i]], [[7o6j]], [[7o6k]], [[7o6m]], [[7ob8]], [[7obd]], [[7obh]], [[7obl]], [[7obt]], [[7oby]], [[7opw]], [[7oq7]], [[7oq8]], [[7oq9]], [[7oqa]], [[7oqg]], [[7oqj]], [[7oqs]], [[7oqu]], [[7oqw]], [[7or3]], [[7or5]], [[7or7]], [[7or8]], [[7org]], [[7orh]], [[7ors]], [[7ort]] – hPRS + peptide + stabilizer<br /> | + | **[[3iqv]], [[3o8i]], [[3p1o]], [[3ux0]], [[4fr3]], [[6ghp]], [[6rws]], [[6s39]], [[6y3w]], [[6xxc]], [[6xy5]], [[6y18]], [[6y3a]], [[7axn]], [[7ayf]], [[7az1]], [[7az2]], [[7b9m]], [[7b9r]], [[7b9t]], [[7ba3]], [[7ba5]], [[7ba6]], [[7ba7]], [[7ba8]], [[7ba9]], [[7baa]], [[7bab]], [[7bdp]], [[7bdt]], [[7bdy]], [[7bfw]], [[7bg3]], [[7bgq]], [[7bgr]], [[7bgv]], [[7bgw]], [[7bi3]], [[7biq]], [[7biw]], [[7biy]], ]]7bjb]], [[7bjf]], [[7bjl]], [[7bjw]], [[7bkh]], [[7bmc]], [[7nif]], [[7nig]], [[7niz]], [[7nj6]], [[7nj8]], [[7nj9]], [[7nja]], [[7njb]], [[7nk3]], [[7nk5]], [[7nle]], [[7nm3]], [[7nqp]], [[7nrk]], [[7nrl]], [[7nla]], [[7nm1]], [[7nm9]], [[7nmh]], [[7nr7]], [[7nsv]], [[7nv4]], [[7nvi]], [[7nws]], [[7nxs]], [[7nxt]], [[7nxw]], [[7nxy]], [[7ny4]], [[7nyf]], [[7nz6]], [[7nzg]], [[7nye]], [[7nyg]], [[7nzk]], [[7nzv]], [[7o34]], [[7o3a]], [[7o3f]], [[7o3p]], [[7o3q]], [[7o3r]], [[7o3s]], [[7o57]], [[7o59]], [[7o5a]], [[7o5c]], [[7o5d]], [[7o5f]], [[7o5g]], [[7o5o]], [[7o5p]], [[7o5s]], [[7o5u]], [[7o5x]], [[7o6f]], [[7o6g]], [[7o6i]], [[7o6j]], [[7o6k]], [[7o6m]], [[7ob8]], [[7obd]], [[7obh]], [[7obl]], [[7obt]], [[7oby]], [[7opw]], [[7oq7]], [[7oq8]], [[7oq9]], [[7oqa]], [[7oqg]], [[7oqj]], [[7oqs]], [[7oqu]], [[7oqw]], [[7or3]], [[7or5]], [[7or7]], [[7or8]], [[7org]], [[7orh]], [[7ors]], [[7ort]], [[7pwt]], [[7pwz]], [[8a62]], [[8a65]], [[8a68]], [[8a6f]], [[8a6h]], [[8adm]], [[8afn]], [[8ai0]], [[8alr]], [[8alt]], [[8alv]], [[8alw]], [[[8am7]], [8anc]], [[8anf]], [[8aoy]], [[8aps]], [[8ar4]], [[8ar5]], [[8arg]], [[8aro]], [[8arq]], [[8arr]], [[8arw]], [[8arx]], [[8ary]], [[8arz]], [[8aq1]], [[8aqc]], [[8aqe]], [[8aqz]], [[8as1]], [[8at9]], [[8atp]], [[8atr]], [[8ats]], [[8au2]], [[8aus]], [[8auy]], [[8av0]], [[8av3]], [[8av4]], [[8av7]], [[8av8]], [[8awg]], [[8axe]], [[8axu]], [[8aze]], [[8b2i]], [[8b2k]], [[8b39]], [[8b4q]], [[8b5p]], [[8bjg]], [[8bjn]], [[8bm5]], [[8btq]], [[8bwe]], [[8bwh]], [[8bwj]], [[8bwx]], [[8bwz]], [[8bxi]], [[8bxm]], [[8bxn]], [[8bxq]], [[8bxs]], [[8byb]], [[8byc]], [[8byd]], [[8bye]], [[8byg]], [[8byo]], [[8byy]], [[8byz]], [[8bz9]], [[8bz0]], [[8bza]], [[8bzb]], [[8bzc]], [[8bzd]], [[8bze]], [[8bzf]], [[8bzg]], [[8bzh]], [[8bzt]], [[8bzw]], [[8c0l]], [[8c1y]], [[8c2g]], [[8c30]], [[8c3c]], [[8c42]], [[8c43]], [[8c4f]], [[8c4g]] – hPRS + peptide + stabilizer<br /> |
**[[3p1q]], [[3p1s]], [[3spr]], [[3smk]], [[3sml]], [[3smm]], [[3smn]], [[3smo]], [[3sp5]] – hPRS (mutant) + peptide + stabilizer<br /> | **[[3p1q]], [[3p1s]], [[3spr]], [[3smk]], [[3sml]], [[3smm]], [[3smn]], [[3smo]], [[3sp5]] – hPRS (mutant) + peptide + stabilizer<br /> | ||
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**[[3u9x]], [[6tm7]] – hPRS + pyridoxal phosphate<br /> | **[[3u9x]], [[6tm7]] – hPRS + pyridoxal phosphate<br /> | ||
| - | **[[3t0l]], [[3t0m]], [[4dhm]], [[4dhn]], [[4dho]], [[4dhp]], [[4dhq]], [[4dhr]], [[4dhs]], [[4dht]], [[4dhu]] – hPRS + inhibitor<br /> | + | **[[3t0l]], [[3t0m]], [[4dhm]], [[4dhn]], [[4dho]], [[4dhp]], [[4dhq]], [[4dhr]], [[4dhs]], [[4dht]], [[4dhu]], [[6ye9]] – hPRS + inhibitor<br /> |
**[[5oeh]], [[5oeg]] – hPRS + molecular tweezers<br /> | **[[5oeh]], [[5oeg]] – hPRS + molecular tweezers<br /> | ||
**[[6tlf]] – hPRS + IMP <br /> | **[[6tlf]] – hPRS + IMP <br /> | ||
**[[6qdu]] – hPRS + phosphothreonine <br /> | **[[6qdu]] – hPRS + phosphothreonine <br /> | ||
| + | |||
| + | *14-3-3 protein σ binary complex with protein | ||
| + | |||
| + | **[[8q4l]] – hPRS + GBP1 – Cryo EM<br /> | ||
*14-3-3 protein ζ | *14-3-3 protein ζ | ||
**[[6uan]] – hPRS + Raf peptide – Cryo EM<br /> | **[[6uan]] – hPRS + Raf peptide – Cryo EM<br /> | ||
| + | **[[8chf]], [[8cpd]] – hPRS + CRaf – Cryo EM<br /> | ||
| + | **[[9axa]] – hPRS + CRaf + MEK + peptide – Cryo EM<br /> | ||
| + | **[[4wrq]], [[4zdr]], [[6f08]], [[6f09]], [[6ymo]], [[6yo8]], [[6yos]], [[7d8h]], [[8ah2]] – hPRS + peptide <br /> | ||
**[[6zfd]] – hPRS/protein E6 <br /> | **[[6zfd]] – hPRS/protein E6 <br /> | ||
**[[6zfg]] – hPRS/protein E6 + stabilizer<br /> | **[[6zfg]] – hPRS/protein E6 + stabilizer<br /> | ||
**[[7q16]] – hPRS/BAD peptide <br /> | **[[7q16]] – hPRS/BAD peptide <br /> | ||
| - | **[[ | + | **[[8a9g]] – hPRS + peptide + stabilizer<br /> |
**[[1a4o]] – bPRS - bovine<br /> | **[[1a4o]] – bPRS - bovine<br /> | ||
**[[1a37]], [[1a38]] – bPRS + peptide <br /> | **[[1a37]], [[1a38]] – bPRS + peptide <br /> | ||
**[[7exe]] – mPRS + ADAM22 peptide - mouse<br /> | **[[7exe]] – mPRS + ADAM22 peptide - mouse<br /> | ||
| - | **[[6nyb]], [[6q0j]], [[6q0t]] – | + | **[[6nyb]], [[6q0j]], [[6q0t]] – baPRS + B-Raf + MKK1 – beet armyworm – Cryo EM<br /> |
| + | **[[8dgs]], [[8dgt]] – baPRS + B-Raf + MKK1 + Kras – Cryo EM<br /> | ||
*14-3-3 protein ζ/δ | *14-3-3 protein ζ/δ | ||
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**[[3rdh]] – hPRS <br /> | **[[3rdh]] – hPRS <br /> | ||
**[[3rdh]] – hPRS/LKB1 <br /> | **[[3rdh]] – hPRS/LKB1 <br /> | ||
| - | **[[1qja]], [[1qjb]], [[2c1j]], [[2c1n]], [[2o02]], [[2v7d]], [[2wh0]], [[3cu8]], [[3nkx]], [[4bg6]], [[4fj3]], [[4hkc]], [[4ihl]], [[4n7g]], [[4n7y]], [[4n84]], [[5d2d]], [[5ewz]], [[5exa]], [[5j31]], [[5jm4]], [[5m35]], [[5m36]], [[5m37]], [[5nas]], [[5ulo]], [[ | + | **[[1qja]], [[1qjb]], [[2c1j]], [[2c1n]], [[2o02]], [[2v7d]], [[2wh0]], [[3cu8]], [[3nkx]], [[4bg6]], [[4fj3]], [[4hkc]], [[4ihl]], [[4n7g]], [[4n7y]], [[4n84]], [[5d2d]], [[5ewz]], [[5exa]], [[5j31]], [[5jm4]], [[5m35]], [[5m36]], [[5m37]], [[5nas]], [[5ulo]], [[5wxn]], [[6f5]], [[6ejl]], [[6eww]], [[6f08]], [[6rlz]], [[7d8p]], [[7d9v]], [[7dh8]] – hPRS + peptide <br /> |
**[[5d3f]] – hPRS + CFTR peptide + stabilizer<br /> | **[[5d3f]] – hPRS + CFTR peptide + stabilizer<br /> | ||
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**[[1ib1]] – hPRS + serotonin N-acetyltransferase <br /> | **[[1ib1]] – hPRS + serotonin N-acetyltransferase <br /> | ||
**[[6fn9]], [[6fna]], [[6fnb]], [[6fnc]] – hPRS + inhibitor<br /> | **[[6fn9]], [[6fna]], [[6fnb]], [[6fnc]] – hPRS + inhibitor<br /> | ||
| - | |||
| - | *14-3-3 protein γ | ||
| - | |||
| - | **[[4e2e]] – hPRS <br /> | ||
| - | **[[2b05]], [[3uzd]], [[4j6s]], [[4o46]], [[5d3e]], [[6a5q]], [[6byj]], [[6byl]], [[6fel]], [[6gkf]], [[6gkg]], [[6s9k]], [[6sad]], [[7a6r]], [[7a6y]] – hPRS + peptide <br /> | ||
| - | **[[6bzd]] – hPRS (mutant) + O-GlcNAc peptide <br /> | ||
| - | **[[6y4k]], [[6y6b]] – hPRS + CaMKK 2 peptide + stabilizer<br /> | ||
*14-3-3 protein β | *14-3-3 protein β | ||
| + | **[[8eq8]] – hPRS <br /> | ||
**[[7qi1]] – hPRS + CFTR peptide + stabilizer<br /> | **[[7qi1]] – hPRS + CFTR peptide + stabilizer<br /> | ||
*14-3-3 protein β/α | *14-3-3 protein β/α | ||
| - | **[[2bq0]], [[4dnk]] – hPRS <br /> | + | **[[2bq0]], [[4dnk]], [[8eqh]] – hPRS <br /> |
**[[2c23]], [[5n10]], [[6a5q]], [[6byk]], [[6gn0]], [[6gn8]], [[6gnj]], [[6gnk]], [[6gnn]], [[6hep]] – hPRS + peptide <br /> | **[[2c23]], [[5n10]], [[6a5q]], [[6byk]], [[6gn0]], [[6gn8]], [[6gnj]], [[6gnk]], [[6gnn]], [[6hep]] – hPRS + peptide <br /> | ||
**[[6ygj]] – hPRS + ChREBP peptide + stabilizer<br /> | **[[6ygj]] – hPRS + ChREBP peptide + stabilizer<br /> | ||
**[[4gnt]] – mPRS + ChREBP peptide <br /> | **[[4gnt]] – mPRS + ChREBP peptide <br /> | ||
**[[5f74]] – mPRS + ChREBP + AMP<br /> | **[[5f74]] – mPRS + ChREBP + AMP<br /> | ||
| - | **[[5wfu]] – mPRS + malate <br /> | + | **[[5wfu]], [[5wfx]] – mPRS + malate <br /> |
| + | |||
| + | *14-3-3 protein β/α + 14-3-3 protein epsilon | ||
| + | |||
| + | **[[8dp5]] – hPRS + PEAK3 + peptide – Cryo EM <br /> | ||
| + | |||
| + | |||
| + | *14-3-3 protein γ | ||
| + | |||
| + | **[[4e2e]] – hPRS <br /> | ||
| + | **[[2b05]], [[3uzd]], [[4j6s]], [[4o46]], [[5d3e]], [[6a5q]], [[6a5s]], [[6byj]], [[6byl]], [[6fel]], [[6gkf]], [[6gkg]], [[6s9k]], [[6sad]], [[6zc9]], [[7a6r]], [[7a6y]] – hPRS + peptide <br /> | ||
| + | **[[6bzd]] – hPRS (mutant) + O-GlcNAc peptide <br /> | ||
| + | **[[6y4k]], [[6y6b]] – hPRS + CaMKK 2 peptide + stabilizer<br /> | ||
| + | |||
| + | *14-3-3 protein delta | ||
| + | |||
| + | **[[8c2f]] – hPRS + peptide<br /> | ||
| + | |||
| + | *14-3-3 protein ε | ||
| + | |||
| + | **[[2br9]], [[6eih]], [[8dgm]], [[8dgn]], [[8dgp]], [[8q1s]] – hPRS + phosphopeptide <br /> | ||
| + | **[[3ual]], [[3ubw]] – hPRS + myeloid leukemia factor 1 peptide <br /> | ||
| + | **[[7c8e]] – hPRS + 9J10 peptide <br /> | ||
*14-3-3 protein θ | *14-3-3 protein θ | ||
**[[5iqp]] – hPRS <br /> | **[[5iqp]] – hPRS <br /> | ||
| - | **[[2btp]] – hPRS + phosphopeptide <br /> | + | **[[2btp]], [[6kzg]], [[6kzh]] – hPRS + phosphopeptide <br /> |
**[[6bcr]], [[6bcy]], [[6bd1]], [[6bd2]], [[6bqt]] – hPRS + IRSp53 peptide <br /> | **[[6bcr]], [[6bcy]], [[6bd1]], [[6bd2]], [[6bqt]] – hPRS + IRSp53 peptide <br /> | ||
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**[[5yqg]] – hPRS + NUMB peptide <br /> | **[[5yqg]] – hPRS + NUMB peptide <br /> | ||
**[[7nmz]] – hPRS + E3 ubiquitin-protein ligase NEDD4-like <br /> | **[[7nmz]] – hPRS + E3 ubiquitin-protein ligase NEDD4-like <br /> | ||
| - | |||
| - | *14-3-3 protein ε | ||
| - | |||
| - | **[[2br9]], [[6eih]] – hPRS + phosphopeptide <br /> | ||
| - | **[[3ual]], [[3ubw]] – hPRS + myeloid leukemia factor 1 peptide <br /> | ||
| - | **[[7c8e]] – hPRS + 9J10 peptide <br /> | ||
*14-3-3 protein | *14-3-3 protein | ||
| - | **[[3efz]] – PRS + phosphoserine – Cryptosporidium parvum<br /> | + | **[[2npm]], [[3efz]] – PRS + phosphoserine – Cryptosporidium parvum<br /> |
| - | **[[4f7r]] – | + | **[[4f7r]], [[5by9]] – GiPRS – Giardia intestinalis<br /> |
| + | **[[4zq0]] – GiPRS + phosphoserine <br /> | ||
| + | **[[8hew]] – PRS + peptide – potato<br /> | ||
| + | **[[6qk8]] – PRS + peptide – yeast<br /> | ||
*14-3-3-like protein C | *14-3-3-like protein C | ||
Current revision
3D structures of 14-3-3 protein
Updated on 17-September-2025 - For a general description of the protein see 14-3-3 protein
