7yj2

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'''Unreleased structure'''
 
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The entry 7yj2 is ON HOLD until 2024-07-19
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==Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex==
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<StructureSection load='7yj2' size='340' side='right'caption='[[7yj2]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7yj2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YJ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yj2 OCA], [https://pdbe.org/7yj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7yj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yj2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ORML3_HUMAN ORML3_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry. SNPs on 17q21 locus that are associated with childhood asthma also show a consistent and strong association with transcript levels of ORMDL3, indicating that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.<ref>PMID:17611496</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ORML3_HUMAN ORML3_HUMAN] Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505, PubMed:30700557, PubMed:37308477). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (PubMed:37308477).<ref>PMID:20182505</ref> <ref>PMID:30700557</ref> <ref>PMID:37308477</ref>
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Authors:
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==See Also==
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*[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gong X]]
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[[Category: Liu P]]
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[[Category: Xie T]]

Current revision

Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex

PDB ID 7yj2

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