1hz6

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[[Image:1hz6.jpg|left|200px]]
 
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==CRYSTAL STRUCTURES OF THE B1 DOMAIN OF PROTEIN L FROM PEPTOSTREPTOCOCCUS MAGNUS WITH A TYROSINE TO TRYPTOPHAN SUBSTITUTION==
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The line below this paragraph, containing "STRUCTURE_1hz6", creates the "Structure Box" on the page.
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<StructureSection load='1hz6' size='340' side='right'caption='[[1hz6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hz6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Finegoldia_magna_ATCC_29328 Finegoldia magna ATCC 29328]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZ6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hz6 OCA], [https://pdbe.org/1hz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1hz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hz6 ProSAT]</span></td></tr>
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{{STRUCTURE_1hz6| PDB=1hz6 | SCENE= }}
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</table>
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== Function ==
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'''CRYSTAL STRUCTURES OF THE B1 DOMAIN OF PROTEIN L FROM PEPTOSTREPTOCOCCUS MAGNUS WITH A TYROSINE TO TRYPTOPHAN SUBSTITUTION'''
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[https://www.uniprot.org/uniprot/Q51912_FINMA Q51912_FINMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The three-dimensional structure of a tryptophan-containing variant of the IgG-binding B1 domain of protein L has been solved in two crystal forms to 1.7 and 1.8 A resolution. In one of the crystal forms, the entire N-terminal histidine-tag region was immobilized through the coordination of zinc ions and its structural conformation along with the zinc coordination scheme were determined. However, the ordering of the histidine tag by zinc does not affect the overall structure of the rest of the protein. Structural comparisons of the tryptophan-containing variant with an NMR-derived wild-type structure, which contains a tyrosine at position 47, reveals a common fold, although the overall backbone root-mean-square difference is 1.5 A. The Y47W substitution only caused local rearrangement of several side chains, the most prominent of which is the rotation of the Tyr34 side chain, resulting in a 6 A displacement of its hydroxyl group. A small methyl-sized cavity bounded by beta-strands 1, 2 and 4 and the alpha-helix was found in the structures of the Y47W-substituted protein L B1 domain. This cavity may be created as the result of subsequent side-chain rearrangements caused by the Y47W substitution. These high-resolution structures of the tryptophan-containing variant provide a reference frame for the analysis of thermodynamic and kinetic data derived from a series of mutational studies of the protein L B1 domain.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hz6_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1HZ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZ6 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hz6 ConSurf].
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Structures of the B1 domain of protein L from Peptostreptococcus magnus with a tyrosine to tryptophan substitution., O'Neill JW, Kim DE, Baker D, Zhang KY, Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):480-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11264576 11264576]
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<div style="clear:both"></div>
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[[Category: Finegoldia magna]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Baker, D.]]
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[[Category: Finegoldia magna ATCC 29328]]
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[[Category: Kim, D E.]]
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[[Category: Large Structures]]
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[[Category: Neill, J W.O.]]
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[[Category: Baker D]]
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[[Category: Zhang, K Y.J.]]
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[[Category: Kim DE]]
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[[Category: Binds kappa light chain of immunoglobulin]]
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[[Category: O'Neill JW]]
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[[Category: Four stranded beta-sheet with central alpha helix]]
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[[Category: Zhang KYJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:23:13 2008''
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Current revision

CRYSTAL STRUCTURES OF THE B1 DOMAIN OF PROTEIN L FROM PEPTOSTREPTOCOCCUS MAGNUS WITH A TYROSINE TO TRYPTOPHAN SUBSTITUTION

PDB ID 1hz6

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