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8a38
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==RING domain of human TRIM2== | |
| - | + | <StructureSection load='8a38' size='340' side='right'caption='[[8a38]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8a38]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A38 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.196Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a38 OCA], [https://pdbe.org/8a38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a38 RCSB], [https://www.ebi.ac.uk/pdbsum/8a38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a38 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TRIM2_HUMAN TRIM2_HUMAN] Charcot-Marie-Tooth disease type 2R. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRIM2_HUMAN TRIM2_HUMAN] UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.[UniProtKB:Q9ESN6] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hennig J]] | ||
| + | [[Category: Murciano B]] | ||
| + | [[Category: Perez-Borrajero C]] | ||
Current revision
RING domain of human TRIM2
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