8ar3

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'''Unreleased structure'''
 
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The entry 8ar3 is ON HOLD
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==Solution structure of TLR9 transmembrane and cytoplasmic juxtamembrane regions==
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<StructureSection load='8ar3' size='340' side='right'caption='[[8ar3]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ar3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar3 OCA], [https://pdbe.org/8ar3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR9_HUMAN TLR9_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:14716310). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).[UniProtKB:Q9EQU3]<ref>PMID:11564765</ref> <ref>PMID:14716310</ref> <ref>PMID:17932028</ref> <ref>PMID:23857366</ref>
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Authors:
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arseniev AS]]
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[[Category: Goncharuk MV]]
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[[Category: Goncharuk SA]]
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[[Category: Kornilov FD]]
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[[Category: Mineev KS]]
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[[Category: Shabalkina AV]]

Current revision

Solution structure of TLR9 transmembrane and cytoplasmic juxtamembrane regions

PDB ID 8ar3

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OCA

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