8e1t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:16, 25 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8e1t is ON HOLD until Paper Publication
+
==Asp1 kinase in complex with ADPNP Mg IP7==
-
 
+
<StructureSection load='8e1t' size='340' side='right'caption='[[8e1t]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
-
Authors: Goldgur, Y., Shuman, S., Benjamin, B.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8e1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E1T FirstGlance]. <br>
-
Description: Asp1 kinase in complex with ADPNP Mg IP7
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=I7P:(1R,2R,3S,4S,5R,6S)-2,3,4,5,6-PENTAKIS(PHOSPHONOOXY)CYCLOHEXYL+TRIHYDROGEN+DIPHOSPHATE'>I7P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
[[Category: Benjamin, B]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e1t OCA], [https://pdbe.org/8e1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e1t RCSB], [https://www.ebi.ac.uk/pdbsum/8e1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e1t ProSAT]</span></td></tr>
-
[[Category: Goldgur, Y]]
+
</table>
-
[[Category: Shuman, S]]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/VIP1_SCHPO VIP1_SCHPO] Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810). Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (By similarity). Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810). Regulates polarized growth and modulates interphase microtubule cytoskeleton. Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3. Required for growth zone selection (PubMed:25254656).[UniProtKB:O43314][UniProtKB:Q06685]<ref>PMID:10388810</ref> <ref>PMID:25254656</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Schizosaccharomyces pombe]]
 +
[[Category: Benjamin B]]
 +
[[Category: Goldgur Y]]
 +
[[Category: Shuman S]]

Current revision

Asp1 kinase in complex with ADPNP Mg IP7

PDB ID 8e1t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8e1t"
Personal tools