7pdv
From Proteopedia
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| - | ==== | + | ==Crystal structure of RBM5 RRM1-zinc finger in complex with RNA== |
| - | <StructureSection load='7pdv' size='340' side='right'caption='[[7pdv]]' scene=''> | + | <StructureSection load='7pdv' size='340' side='right'caption='[[7pdv]], [[Resolution|resolution]] 3.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7pdv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PDV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pdv OCA], [https://pdbe.org/7pdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pdv RCSB], [https://www.ebi.ac.uk/pdbsum/7pdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pdv ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.49Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pdv OCA], [https://pdbe.org/7pdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pdv RCSB], [https://www.ebi.ac.uk/pdbsum/7pdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pdv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBM5_HUMAN RBM5_HUMAN] Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.<ref>PMID:10949932</ref> <ref>PMID:12207175</ref> <ref>PMID:12581154</ref> <ref>PMID:15192330</ref> <ref>PMID:16585163</ref> <ref>PMID:18851835</ref> <ref>PMID:18840686</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Jagtap PKA]] |
| + | [[Category: Sattler M]] | ||
| + | [[Category: Soni K]] | ||
Current revision
Crystal structure of RBM5 RRM1-zinc finger in complex with RNA
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