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7ru6
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| - | ==== | + | ==Cryo-EM structure of the HIV-1 restriction factor human SERINC3== |
| - | <StructureSection load='7ru6' size='340' side='right'caption='[[7ru6]]' scene=''> | + | <StructureSection load='7ru6' size='340' side='right'caption='[[7ru6]], [[Resolution|resolution]] 4.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ru6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RU6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ru6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ru6 OCA], [https://pdbe.org/7ru6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ru6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ru6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ru6 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ru6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ru6 OCA], [https://pdbe.org/7ru6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ru6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ru6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ru6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SERC3_HUMAN SERC3_HUMAN] Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).<ref>PMID:26416733</ref> <ref>PMID:26416734</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Synthetic construct]] |
| + | [[Category: Leonhardt SA]] | ||
| + | [[Category: Purdy MD]] | ||
| + | [[Category: Yeager M]] | ||
Current revision
Cryo-EM structure of the HIV-1 restriction factor human SERINC3
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